Sickle Cell Disease / Thalassaemias

Red Cell Special Interest Group 3 of 3

Day: Wednesday  |   Time: 15:00 - 16:30  |  Room:  Auditorium

Session Coordinators: 
Lesley Bruce & Vanja Crew

Speakers: 

Genetic modifiers of fetal haemoglobin in sickle cell disease
Stephan Menzel, The Rayne Institute

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Hyperhaemolysis: macrophage the culprit!
Nay Win, NHSBT London

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Genotyping of the haemoglobinopathy patient population in England
Karen DeSay, International Blood Group Reference Laboratory

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Brief Description
The third session of this year's Red Cell SIG, with the theme of sickle cell disease (SCD) and thalassaemias, will focus on novel research which may improve patients' outcomes. Participants will learn about genetic modifiers of fetal haemoglobin in SCD and about hyperhaemolysis, a rare post transfusion reaction seen primarily in patients with SCD. Furthermore, genotyping of the haemoglobinopathy patient population in England will be discussed.

Intended Audience
This Red Cell SIG session should be of interest to biomedical scientists and trainees working in hospital transfusion departments; UK Blood Services and associated services; research scientists involved in red cell and/or basic research work; clinicians who prescribe blood components in haematology, surgery, intensive care, obstetrics and trauma settings; transfusion practitioners; anyone in the wider scientific community who is interested in the current red cell research carried out in the UK.

Learning Objectives

1) Learning about the progress in understanding the genetic control of modifiers of fetal haemoglobin and its clinically beneficial effect in sickle cell disease

2) Introduction to complex pathogenesis of hyperhaemolysis resulting in the destruction of both transfused and patient’s own RBC by activated macrophages

3) Learning about the prevalence of Rh variant phenotypes and rate of immunisation in the haemoglobinopathy patient population in England.

Session Tags
Improving Patient Outcomes
Diagnostics, Science & Technology
Education